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In one embodiment, a compound of Formula (I) or a salt or a prodrug thereof is provided wherein X is CR.sub.4; R.sub.4 is H, halo, C.sub.1-4 alkyl, C.sub.1-4 fluoroalkyl, or C.sub.3-6 cycloalkyl; and Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.5 are defined in the first aspect. In one embodiment, a compound of Formula (I) or a salt or a prodrug thereof is provided wherein each R.sub.1a is independently H or C.sub.1-2 alkyl; each R.sub.1b is independently H, F, —CH.sub.3, —CHF.sub.2, or cyclopropyl; or two R.sub.1b along with the carbon atom to which they are attached form a 3-membered spirocycloalkyl ring; and X, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are defined in the first aspect. In one embodiment, a compound of Formula (I) or a salt or a prodrug thereof is provided wherein Y is CR.sub.5; R.sub.5 is H, halo, C.sub.1-4 alkyl, C.sub.1-4 fluoroalkyl, or C.sub.3-6 cycloalkyl; and Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the first aspect.

Also, included in this embodiment are compounds in which R.sub.1a and R.sub.1b along with the carbon atoms to which they are attached, form a 4-membered cycloalkyl ring. In one embodiment, a compound of Formula (I) or a salt or a prodrug thereof is provided wherein each R.sub.1a is independently H, —OH, F, C.sub.1-3 alkyl, C.sub.1-2 fluoroalkyl, C.sub.1-2 alkoxy, C.sub.1-2 fluoroalkoxy, or C.sub.3-6 cycloalkyl; or two R.sub.1a along with the carbon atom to which they are attached, can form a 3- to 4-membered spirocycloalkyl ring; each R.sub.1b is independently H, —OH, F, C.sub.1-2 alkyl, C.sub.1-2 fluoroalkyl, C.sub.1-2 alkoxy, C.sub.1-2 fluoroalkoxy, or C.sub.3-6 cycloalkyl; or two R.sub.1b along with the carbon atom to which they are attached, can form a 3- to 4-membered spirocycloalkyl ring; each R.sub.1c is independently H, F, C.sub.1-2 alkyl, C.sub.1-2 fluoroalkyl, or C.sub.3-6 cycloalkyl; or two R.sub.1c along with the carbon atom to which they are attached, can form a 3- to 4-membered spirocycloalkyl ring; R.sub.2 is H, F, Cl, C.sub.1-2 alkyl, or C.sub.3-6 cycloalkyl; R.sub.3 is C.sub.1-3 alkoxy, C.sub.1-2 fluoroalkoxy, or C.sub.3-6 cycloalkoxy; R.sub.4 is H, halo, C.sub.1-4 alkyl, C.sub.1-4 fluoroalkyl, or C.sub.3-6 cycloalkyl; R.sub.5 is H, halo, C.sub.1-4 alkyl, C.sub.1-4 fluoroalkyl, or C.sub.3-6 cycloalkyl; and X, Y, and R.sub.1 are defined in the first aspect.

In one embodiment, a compound of Formula (I) or a salt or a prodrug thereof is provided wherein each R.sub.1a is independently H or C.sub.1-2 alkyl; each R.sub.1b is independently H, F, —CH.sub.3, —CHF.sub.2, or cyclopropyl; or two R.sub.1b along with the carbon atom to which they are attached, can form a 3-membered spirocycloalkyl ring; each R.sub.1c is H; R.sub.2 is H or —CH.sub.3; R.sub.3 is —OCH.sub.3, —OCH(CH.sub.3).sub.2, or —O(cyclopropyl); R.sub.4 is H; R.sub.5 is H; and X, Y, and R.sub.1 are defined in the first aspect. The term «spirocycloalkyl» refers to a carbocyclyl ring attached to the molecular moiety by a carbon atom in the cycloalkyl ring that is shared with the molecular moiety. The term «solvate» means a physical association of a compound of Formula (I) with one or more solvent molecules, whether organic or inorganic. This physical association includes hydrogen bonding. The term «cycloalkyl,» as used herein, refers to a group derived from a non-aromatic monocyclic or polycyclic hydrocarbon molecule by removal of one hydrogen atom from a saturated ring carbon atom. The term «alkyl» as used herein, refers to both branched and girl cam chat straight-chain saturated aliphatic hydrocarbon groups containing, for example, from 1 to 12 carbon atoms, from 1 to 6 carbon atoms, and from 1 to 4 carbon atoms.

The term «amino» refers to the group —NH.sub.2. As used herein, the phase «compounds» refers to at least one compound. In certain instances the solvate will be capable of isolation, for example when one or more solvent molecules are incorporated in the crystal lattice of the crystalline solid. Included in this embodiment are compounds in which R.sub.1a and R.sub.1b along with the carbon atoms to which they are attached, form a 3-membered cycloalkyl ring. Also, included in this embodiment are compounds in which R.sub.1b and R.sub.1c along with the carbon atoms to which they are attached, form a 4-membered cycloalkyl ring. The majority of plants recovered are estimated to contain only 1-2 copies of the cassette encoded in the donor DNA. First the sperm donor will ejaculate into a completely sterile container, after which it should be carefully sealed until it is ready to be inserted into the vagina. Refined or processed carbohydrates, a diet which regularly contains breads, pastas, baked goods, and other grains will elevate insulin levels. If they have no blacklisted traits, then one of their main CAS traits will be replaced with the pheromonal Flower trait. In addition, compounds of Formula (I), subsequent to their preparation, can be isolated and purified to obtain a composition containing an amount by weight equal to or greater than 99% of a compound of Formula (I) («substantially pure»), which is then used or formulated as described herein.

The Purchase Agreement prohibits us from directing Lincoln Park to purchase any shares of common stock if those shares, when aggregated with all other shares of our common stock then beneficially owned by Lincoln Park, would result in Lincoln Park and its affiliates exceeding the Beneficial Ownership Cap. On April 5, 2018, the Company announced that it had entered into a Securities Purchase Agreement (the «SPA») with APF, an Arkansas corporation, and Andy Galbach («Galbach») and Clarence Carl Davis, Jr. («Davis»), the owners of APF (the «Sellers»). On October 4, 2017, Kevin Cannon and Michelle Hanby, individually and on behalf of It’s a Date LLC and Brake Plus NWA, Inc., filed a lawsuit in the Arizona Superior Court, Maricopa County, against the Company and several other defendants, including Jeff Hail, the Company’s Sr. Vice President. First date is cost to have more personal alone. In a Vice documentary about Hill and her run for office, Desjardins was seen constantly at Hill’s side, as well as a clip from when she was lying on a bed with Heslep, watching Hill have her hair done. The show’s main character Carrie Bradshaw — played by Sarah Jessica Parker — was to be seen being blocked when she tried to get onto a roped off New York subway which had been closed by the authorities.