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> Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure is related. On joining the chat room, players have this option of switching on their web cams and seeing the chat hosts and even the other members available at the rooms. As much as you may crave intimacy, even finding the time to swipe on a profile can be tough-and isn’t the whole point of casual dating that it’s supposed to be fun and stress-free for everyone? You can get astonished to comprehend there are quite a lot of star styles in New Jersey offering their New Jersey Escort Expert services even as getting an enormous costs together with the rather finest good quality of pleasurable. This activity offers you a lot fabulous illustrations. FIG. 2: Graph showing inhibition of AMPA mediated calcium oscillations by antisense oligomers as an indication of neuronal network activity disruption. E81. In a method of testing or determining in vivo neurotoxicity of a molecule, the improvement comprising measuring calcium oscillations in vitro in neuronal cells which are in contact with the molecule

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> The ASO and other oligomerss that behaved similarly, were shown to negatively impact central nervous system (CNS) network activity in vivo and electrophysiologic spontaneous neuronal activity in vitro (data not shown). FIG. 4: shows the impact of Tau antisense oligonucleotide on spontaneous calcium oscillations in primary neurons. Primary neuronal spontaneous calcium oscillations were measured as described previously (Murphy et. FIG. 1: Graph demonstrating primary neuronal spontaneous calcium oscillations. Calcium oscillations were reduced further, by about 80%, when N-methyl-D-aspartate (NMDA) receptor function was blocked by 1 mM MgCl.sub.2 (NMDA labeled bar shown). Addition of 25 .mu.M antisense oligomers (TGTgatgcaggaGTT) (SEQ ID NO: 304) (ASO-00007) inhibited AMPA receptor but not NMDA receptor mediated oscillations. Antisense oligomer inhibition of spontaneous calcium oscillations mediated by either NMDA or AMPA was assessed in the presence or absence of 1 mM MgCl.sub.2 (representing 100% control in each case). E79. An antisense oligonucleotide for sexy naked females use in treating a neurological disease or condition in a subject in need thereof, wherein calcium oscillations in neuronal cells that are in contact with the antisense oligonucleotide are about 70% or higher, about 75% or higher, about 80% or higher, about 85% or higher, about 90% or higher, about 95% or higher, about 96% or higher, about 97% or higher, about 98% or higher, about 99% or higher, about 100% or higher, about 120% or higher, about 140% or higher, about 160% or higher, about 180% or higher, about 200% or higher, about 220% or higher, about 240% or higher, or about 250% or higher compared to the calcium oscillations in vehicle control cells

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> E76. The method of any one of Embodiments 63 to 74, wherein when the molecule is administered to laboratory animals, more than 85% of the animals survive. E59. The method of any one of embodiments 1 to 58, wherein when the molecule is administered to laboratory animals, more than 85% of the animals survive. E66. The method of any one of Embodiments 63 to 65, wherein the calcium oscillations are AMPA receptor dependent. E82. In a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity, the improvement comprising measuring calcium oscillations in vitro in neuronal cells which are in contact with the molecule, wherein the neuronal cells in contact with the molecule exhibit calcium oscillations at a level comparable to or higher than that of vehicle control cells. E63. A method of testing or determining in vivo acute neurotoxicity of a molecule comprising the steps of 1) adding the molecule to a culture of neuronal cells and 2) measuring calcium oscillations in vitro in the neuronal cells. E86. In the methods of Embodiments 81 to 85, the improvement further comprising measuring reduction of in vitro expression of a target protein of the molecul

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